Talent there for the taking

For the draft's final two days, be sure to follow along with Mike Clay's NFL Draft Tracker, which updates each selection and also provides full details as each draft-day trade unfolds.

Adam Levitan recalls the most memorable moments of day one.

This is my mock projection of the next two rounds:

33. Jaguars -- Syracuse QB Ryan Nassib

Day One Addition(s): RT Luke Joeckel

Nassib is strongly rumored to be the top QB on Jacksonville's board.

34. 49ers -- Stanford TE Zach Ertz

Day One Addition(s): FS Eric Reid

Ertz is a pass-catching upgrade in the old Delanie Walker role.

35. Eagles -- Alabama NT Jesse Williams

Day One Addition(s): RT Lane Johnson

Philly's defense gets more physical by selecting immovable Williams.

36. Lions -- Florida State OT Menelik Watson

Day One Addition(s): RE Ezekiel Ansah

Offensive line is Detroit's biggest need after the Ansah pick.

37. Bengals -- Florida International S Johnathan Cyprien

Day One Addition(s): TE Tyler Eifert

The Bengals may have drafted Cyprien 21st had Eifert not fallen.

38. Cardinals -- North Carolina State QB Mike Glennon

Day One Addition(s): RG Jonathan Cooper

Carson Palmer is 33. Glennon becomes Bruce Arians' QB of the future.

39. Jets -- West Virginia QB Geno Smith

Day One Addition(s): CB Dee Milliner, DT Sheldon Richardson

The Jets' focus turns to offense on day two. Geno is their top QB.

40. Titans -- Florida State DE Tank Carradine

Day One Addition(s): RG Chance Warmack

Tennessee needs another pass rusher to mask its shaky secondary.

41. Bills -- Tennessee WR Justin Hunter

Day One Addition(s): QB E.J. Manuel

Hunter is the field stretcher Buffalo has lacked since Lee Evans' prime.

42. Raiders -- Kentucky OG Larry Warford

Day One Addition(s): CB D.J. Hayden

The Raiders are desperate for power blockers. Warford is a mauler.

43. Buccaneers -- Cincinnati TE Travis Kelce

Day One Addition(s): CB Darrelle Revis

Kelce is a fantastic all-around tight end and can start right away.

44. Panthers -- Boise State CB Jamar Taylor

Day One Addition(s): DT Star Lotulelei

After stealing Star, cornerback leaps atop Carolina's list of needs.

45. Chargers -- Arkansas-Pine Bluff LT Terron Armstead

Day One Addition(s): RT D.J. Fluker

GM Tom Telesco isn't finished adding talent to a brutal offensive line.

46. Bills -- Kansas State ILB Arthur Brown

The Bills add physicality at inside 'backer by picking thumper Brown.

47. Cowboys -- South Carolina S D.J. Swearinger

Day One Addition(s): G/C Travis Frederick

With the O-Line squared away, safety is Dallas' top remaining need.

48. Steelers -- Alabama RB Eddie Lacy

Day One Addition(s): OLB Jarvis Jones

Lacy is the back the Steelers hoped Jonathan Dwyer would be.

49. Giants -- Notre Dame ILB Manti Te'o

Day One Addition(s): LG Justin Pugh

Te'o is good value here for the middle linebacker-needy G-Men.

50. Bears -- USC QB Matt Barkley

Day One Addition(s): G/T Kyle Long

The Bears put contract-year QB Jay Cutler on notice with this pick.

51. Redskins -- Tennessee Tech WR Da'Rick Rogers

Day One Addition(s): None. See RG3 trade.

Mike Shanahan could envision Rogers as his next Brandon Marshall.

52. Patriots -- SMU DE Margus Hunt

Day One Addition(s): None. Traded out.

The Pats would've considered Hunt had they stayed the 29th pick.

53. Bengals -- North Carolina RB Giovani Bernard

Bernard adds playmaking ability to a backfield that badly needs it.

54. Chiefs (Trade with Dolphins) -- LSU ILB Kevin Minter

Day One Addition(s): LT Eric Fisher

After trading Branden Albert, the Chiefs acquire a plug-and-play starter.

55. Packers -- UCLA RB Johnathan Franklin

Day One Addition(s): RE Datone Jones

GM Ted Thompson can shore up running back long term with Franklin.

56. Seahawks -- San Diego State TE Gavin Escobar

Day One Addition(s): WR Percy Harvin

Long and athletic, Escobar creates mismatches in the passing game.

57. Texans -- Connecticut ILB Sio Moore

Day One Addition(s): WR DeAndre Hopkins

Moore could be a day-one starter next to Brian Cushing inside.

58. Broncos -- Michigan State RB Le'Veon Bell

Day One Addition(s): DT Sylvester Williams

Bell can pass block, which is critical in Peyton Manning's offense.

59. Patriots -- California WR Keenan Allen

The receiver-needy Pats can't pass up the value of Allen at No. 59.

60. Falcons -- Texas A&M DE Damontre Moore

Day One Addition(s): CB Desmond Trufant

Moore needs to get stronger, but he dominated in the SEC.

61. 49ers -- Ohio State DT Johnathan Hankins

Hankins adds bulk and depth to San Francisco's thin defensive line.

62. Ravens -- USC WR Robert Woods

Day One Addition(s): SS Matt Elam

Woods is a classic Z receiver and perfect complement to Torrey Smith.

For the draft's final two days, be sure to follow along with Mike Clay's NFL Draft Tracker, which updates each selection and also provides full details as each draft-day trade unfolds.

Adam Levitan recalls the most memorable moments of day one.

This is my mock projection of the next two rounds:

33. Jaguars -- Syracuse QB Ryan Nassib

Day One Addition(s): RT Luke Joeckel

Nassib is strongly rumored to be the top QB on Jacksonville's board.

34. 49ers -- Stanford TE Zach Ertz

Day One Addition(s): FS Eric Reid

Ertz is a pass-catching upgrade in the old Delanie Walker role.

35. Eagles -- Alabama NT Jesse Williams

Day One Addition(s): RT Lane Johnson

Philly's defense gets more physical by selecting immovable Williams.

36. Lions -- Florida State OT Menelik Watson

Day One Addition(s): RE Ezekiel Ansah

Offensive line is Detroit's biggest need after the Ansah pick.

37. Bengals -- Florida International S Johnathan Cyprien

Day One Addition(s): TE Tyler Eifert

The Bengals may have drafted Cyprien 21st had Eifert not fallen.

38. Cardinals -- North Carolina State QB Mike Glennon

Day One Addition(s): RG Jonathan Cooper

Carson Palmer is 33. Glennon becomes Bruce Arians' QB of the future.

39. Jets -- West Virginia QB Geno Smith

Day One Addition(s): CB Dee Milliner, DT Sheldon Richardson

The Jets' focus turns to offense on day two. Geno is their top QB.

40. Titans -- Florida State DE Tank Carradine

Day One Addition(s): RG Chance Warmack

Tennessee needs another pass rusher to mask its shaky secondary.

41. Bills -- Tennessee WR Justin Hunter

Day One Addition(s): QB E.J. Manuel

Hunter is the field stretcher Buffalo has lacked since Lee Evans' prime.

42. Raiders -- Kentucky OG Larry Warford

Day One Addition(s): CB D.J. Hayden

The Raiders are desperate for power blockers. Warford is a mauler.

43. Buccaneers -- Cincinnati TE Travis Kelce

Day One Addition(s): CB Darrelle Revis

Kelce is a fantastic all-around tight end and can start right away.

44. Panthers -- Boise State CB Jamar Taylor

Day One Addition(s): DT Star Lotulelei

After stealing Star, cornerback leaps atop Carolina's list of needs.

45. Chargers -- Arkansas-Pine Bluff LT Terron Armstead

Day One Addition(s): RT D.J. Fluker

GM Tom Telesco isn't finished adding talent to a brutal offensive line.

46. Bills -- Kansas State ILB Arthur Brown

The Bills add physicality at inside 'backer by picking thumper Brown.

47. Cowboys -- South Carolina S D.J. Swearinger

Day One Addition(s): G/C Travis Frederick

With the O-Line squared away, safety is Dallas' top remaining need.

48. Steelers -- Alabama RB Eddie Lacy

Day One Addition(s): OLB Jarvis Jones

Lacy is the back the Steelers hoped Jonathan Dwyer would be.

49. Giants -- Notre Dame ILB Manti Te'o

Day One Addition(s): LG Justin Pugh

Te'o is good value here for the middle linebacker-needy G-Men.

50. Bears -- USC QB Matt Barkley

Day One Addition(s): G/T Kyle Long

The Bears put contract-year QB Jay Cutler on notice with this pick.

51. Redskins -- Tennessee Tech WR Da'Rick Rogers

Day One Addition(s): None. See RG3 trade.

Mike Shanahan could envision Rogers as his next Brandon Marshall.

52. Patriots -- SMU DE Margus Hunt

Day One Addition(s): None. Traded out.

The Pats would've considered Hunt had they stayed the 29th pick.

53. Bengals -- North Carolina RB Giovani Bernard

Bernard adds playmaking ability to a backfield that badly needs it.

54. Chiefs (Trade with Dolphins) -- LSU ILB Kevin Minter

Day One Addition(s): LT Eric Fisher

After trading Branden Albert, the Chiefs acquire a plug-and-play starter.

55. Packers -- UCLA RB Johnathan Franklin

Day One Addition(s): RE Datone Jones

GM Ted Thompson can shore up running back long term with Franklin.

56. Seahawks -- San Diego State TE Gavin Escobar

Day One Addition(s): WR Percy Harvin

Long and athletic, Escobar creates mismatches in the passing game.

57. Texans -- Connecticut ILB Sio Moore

Day One Addition(s): WR DeAndre Hopkins

Moore could be a day-one starter next to Brian Cushing inside.

58. Broncos -- Michigan State RB Le'Veon Bell

Day One Addition(s): DT Sylvester Williams

Bell can pass block, which is critical in Peyton Manning's offense.

59. Patriots -- California WR Keenan Allen

The receiver-needy Pats can't pass up the value of Allen at No. 59.

60. Falcons -- Texas A&M DE Damontre Moore

Day One Addition(s): CB Desmond Trufant

Moore needs to get stronger, but he dominated in the SEC.

61. 49ers -- Ohio State DT Johnathan Hankins

Hankins adds bulk and depth to San Francisco's thin defensive line.

62. Ravens -- USC WR Robert Woods

Day One Addition(s): SS Matt Elam

Woods is a classic Z receiver and perfect complement to Torrey Smith.

Third-Round Projections

63. Chiefs -- Georgia FS Bacarri Rambo

64. Jaguars -- Mississippi State CB Johnthan Banks

65. Lions -- Auburn DE Corey Lemonier

66. Raiders -- Arkansas QB Tyler Wilson

67. Eagles -- Southern Miss LB Jamie Collins

68. Browns -- Connecticut CB Blidi Wreh-Wilson

69. Cardinals -- Texas DE Alex Okafor

70. Titans -- Oregon State CB Jordan Poyer

71. Rams -- Kent State OG Brian Winters

72. Jets -- West Virginia WR Stedman Bailey

73. Buccaneers -- Georgia NT John Jenkins

74. Cowboys -- Clemson RB Andre Ellington

75. Saints -- Missouri Southern State DT Brandon Williams

76. Chargers -- Syracuse SS Shamarko Thomas

77. Dolphins -- Mississippi State CB Darius Slay

78. Bills -- Tennessee OG Dallas Thomas

79. Steelers -- Texas A&M WR Ryan Swope

80. Cowboys -- Fresno State S Phillip Thomas

81. Giants -- Georgia DE Cornelius Washington

82. Dolphins -- Wisconsin RB Montee Ball

83. Patriots -- Oregon State WR Markus Wheaton

84. Bengals -- Ohio State OT Reid Fragel

85. Redskins -- LSU CB Tyrann Mathieu

86. Colts -- Texas A&M RB Christine Michael

87. Seahawks -- Colorado OG David Bakhtiari

88. Packers -- Georgia Southern SS J.J. Wilcox

89. Texans -- Florida TE Jordan Reed

90. Broncos -- Western Kentucky DE Quanterus Smith

91. Patriots -- Georgia CB Sanders Commings

92. Rams -- North Carolina State S Earl Wolff

93. 49ers -- Marshall WR Aaron Dobson

94. Ravens -- Florida ILB Jon Bostic

95. Texans -- Williams & Mary S B.W. Webb

96. Chiefs -- Connecticut CB Dwayne Gratz

97. Titans -- Purdue DT Kawann Short

Others Considered: Louisiana Tech WR Quinton Patton, SE Louisiana CB Robert Alford, Rice TE Vance McDonald, San Diego State CB Leon McFadden, Missouri WLB Zaviar Gooden, Rutgers WLB Khaseem Greene, North Carolina State CB David Amerson, Arkansas RB Knile Davis.

Source: http://www.rotoworld.com/articles/nfl/43149/60/second-day-mock-draft

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A Hidden Victim of Somali Pirates: Science

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New advances in the management of patients with cirrhosis

Apr. 25, 2013 ? New data from clinical studies presented for the first time at the International Liver Congress? 2013 provide new rationale for an old and established treatment option for portal hypertension. Additionally, spleen stiffness predicts the occurrence of clinical complications, which is of paramount importance in clinical practice.

In patients with cirrhosis, increasing blood pressure in the abdominal circulatory system (known as portal hypertension) leads to potentially lethal complications which might be prevented with simple medical treatment. Patients with cirrhosis and portal hypertension have increased gastrointestinal permeability which allows the movement of bacteria or bacterial components through the lining of the gut into the blood stream in a process known as bacterial translocation. Bacterial components such as lipopolysaccharide can be involved in the genesis of complications of cirrhosis.

The first study evaluated the effects of a non-selective beta-blocker (NSBB) on gastrointestinal permeability and bacterial translocation in patients with cirrhosis with high levels of portal hypertension.1 Patients with severe portal hypertension (HVPG* ?20mmHg) had increased markers of gastrointestinal permeability and bacterial translocation compared to patients with lower levels of portal hypertension (HVPG<20mmHg). Treatment with NSBB significantly reduced HVPG, improved gastrointestinal permeability and decreased bacterial translocation (LPS-binding protein (LBP) -16% p=0.018; IL-6 -41% p< 0.0001) levels.

Patients who were found to have the highest levels of gastrointestinal permeability were also found to be at most risk of bleeding from esophageal varices; a complication of cirrhosis which carries a high risk of mortality.

These findings provide a new rationale for the use of non-selective beta-blockers in patients with cirrhosis. EASL's Treasurer Prof. Mauro Bernardi commented on the data: "The movement of bacteria from the gut and into the bloodstream is extremely serious and potentially fatal in patients with cirrhosis often leading to complications or death. Beta-blockers have been successfully used in a number of conditions and as a standard treatment to control blood pressure in other disease areas. In cirrhosis, they have been used for decades for primary and secondary prophylaxis of bleeding from esophageal varices. The results of this study show that besides improving portal hypertension, as it was thought up to now, their beneficial effects are also due to their ability to reduce bacterial translocation which may widen the indications for the use of these drugs in this setting."

In the diagnostic landscape, promising data to support the validity of non-invasive techniques were also presented at the congress. HVPG, an invasive measurement technique currently considered as the best predictor to identify progression to severe scarring of the liver and disrupted essential body functions (clinical decompensation), was compared to techniques such as the evaluation of spleen stiffness (SS) combined with the MELD** score.2 ?

The study showed that in compensated (early) patients with cirrhosis both the SS (p<0.0001) and the MELD (p=0.016) score provided an accurate prediction of clinical decompensation, and their combination in a new score had a predicting power even superior to that of HVPG.

Prof. Mauro Bernardi added, "HVPG is an invasive technique, which can often be discomforting for patients, is only performed in specialised centres and needs experienced operators to be fully reliable. While further studies will be required, if non-invasive techniques continue to present accurate predictions, they would be welcomed in the overall management of compensated patients with cirrhosis."

Notes

*HVPG or hepatic venous pressure gradient is the most widely used parameter for assessing portal hypertension

**MELD is a scoring system for assessing the severity of chronic liver disease

Compensated cirrhosis, where the body still functions fairly well despite scarring of the liver, is strongly associated with the development of portal hypertension.

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Story Source:

The above story is reprinted from materials provided by European Association for the Study of the Liver, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/d1-eaT2z-v8/130425091610.htm

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93% No

All Critics (96) | Top Critics (31) | Fresh (89) | Rotten (7)

"No" is a picture that perches precariously on the cusp of a paradox.

A cunning and richly enjoyable combination of high-stakes drama and media satire from Chilean director Pablo Larrain.

A mesmerizing, realistic and often hilarious look at the politics of power and the power of ideas ...

A political drama, a personal drama, a sharp-eyed study of how the media manipulate us from all sides, No reels and ricochets with emotional force.

It's a funny look at the way the media warp public opinion, and a curiously hopeful one.

On every level, "No" leaves one with bittersweet feelings about democracy, love and the cost of compromise.

No is a great historical document as to how one very important revolution started with a commercial.

The understated performance by Bernal was inspiring, as was the pic.

It's not easy material but it's truly fascinating, and expertly done.

An extremely perceptive and intriguing examination of the effect that media hype and spin have on the political process.

...a bitter and knowing meditation on media manipulation and political subversion.

Larrain deftly mixes social satire and historical drama.

All historical and little drama.

Larrain does a fine job of making No look and sound authentic to its time period, although the VHS-quality photography, all washed-out with colors bleeding together as camcorders did in the '80s, is an occasional irritant.

Silliness is on the side of the angels in a brilliant and highly entertaining film that's part political thriller, part media satire.

It's clear that the language of advertising has become universal, and that political commodities can be sold like soap. But toppling a dictatorship? Now there's a story.

A reflection of a moment in time, made in the image of that moment.

Bernal deftly explores the layers of the character's complexity, including his political apathy.

"No" is filmmaking of the first order.

Old technology plus the packaging of a revolution add up to a Yes

Freshens up a decades-old story with vibrant humor and a good sense of storytelling.

No continually impresses for its slyness and savvy -- rarely has such an eyesore been so worth watching.

Larrain fashions an unlikely crowd-pleaser from a historical episode that has its share of tragedy as well as triumph.

No quotes approved yet for No. Logged in users can submit quotes.

Source: http://www.rottentomatoes.com/m/no_2012/

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American Airlines to expand flights from Los Angeles hub

(Reuters) - AMR Corp's American Airlines on Wednesday said it plans to expand service from Los Angeles, one of its five major U.S. hubs that is an important business and leisure market, by adding flights to nine cities this year.

American, which plans to merge with US Airways Group Inc and form the world's biggest carrier, said the new destinations from Los Angeles will bring additional flight options to nationwide passengers and enable it to connect more travelers to international markets.

New cities to be served from Los Angeles starting this summer include Pittsburgh; Columbus, Ohio; Indianapolis; and Hartford, Connecticut. Through agreements with feeder carriers, American will also add service to Bentonville, Arkansas, and the Oregon cities of Eugene and Redmond from Los Angeles.

American said service from Los Angeles to Sao Paulo is due to begin in November pending U.S. government approval of its application to add more flights to Brazil from the United States.

In April, American began flying to Raleigh/Durham, North Carolina, from Los Angeles. As a result of the expansion, American will fly to and from 51 U.S. and international cities from Los Angeles.

Virasb Vahidi, American Chief Commercial Officer, said the expansion would strengthen the presence of the oneworld global airline alliance, which is looking to fill gaps in its worldwide network and catch up to rival alliances SkyTeam and Star. Oneworld is led by American and British Airways .

The expanded Los Angeles service "provides a very unique opportunity for us to be able to capture a disproportionate share of high-value customers and corporations," Vahidi said. Other oneworld member airlines such as Japan Airlines, Qantas, Cathay Pacific and BA also operate in Los Angeles.

At Los Angeles International Airport, American is second in passenger market share with 16.3 percent, behind United Continental's 17.6 percent share, according to data for January 2013 through February 2013 provided on the facility's website.

Los Angeles is one of five key U.S. hubs that American, which filed for Chapter 11 bankruptcy in November 2011, is counting on to drive growth. The others are Dallas/Fort Worth, New York, Miami and Chicago.

(Reporting by Karen Jacobs; Editing by Gerald E. McCormick, Phil Berlowitz and Sofina Mirza-Reid)

Source: http://news.yahoo.com/american-airlines-expand-flights-los-angeles-hub-171549543--finance.html

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Microsoft Xbox Next ?Durango? May Cost $500 ? Tech Analyst - X-bit ...

A renowned technology analyst has revealed that while Microsoft?s Corp.?s next-generation video game console will be heavily based on PC technology, it will cost more than an average personal computer. The reasons for Xbox code-named Durango are not completely clear, given the fact that it will compete against mobile devices, PCs and Sony PlayStation 4.

"Durango is going to be expensive ? $500, $300 with a subscription ? that kind of thing. Originally, they were going to announce this thing on April 24. Now they are going to announce it on May 21. We know there are events occurring this year where we are going to learn more about Durango. E3 is going to occur, Build is going to occur in San Francisco in June when they are going to talk about the developer story because it is a Windows 8 device. It is going to have the same, or basically the same, developer tools and developer APIs," said Paul Thurrott, a well-known Microsoft expert, in the recent What The Tech's video podcast.

Microsoft released the Xbox 360 console in the U.S. back in 2005 at $299 and $399 price-points and it has taken the company quite some time to slash pricing of the product to mainstream $199. With models priced at $399 and $499 the software giant will hardly be able to outsell the Xbox 360 game console at least early in the lifecycle. Mr. Thurrott also revealed that according to his sources, the console would require a constant internet connection

It is also rumoured that Microsoft intends to release a low-cost Xbox 360 version code-named Stingray at $99 price-point later this year, bringing value gaming and advanced entertainment capabilities to customers in budget. While the company is clearly interested in such an offering, given that modern Xbox 360 games cost $50 and higher, the Stingray will barely get popular among casual gamers, but will rather be a substitute for those, who want to play current titles that will not work on Xbox Next.

Microsoft Xbox Next ?Durango? is expected to be architecturally similar to the PlayStation 4. It is believed that the future Xbox will be powered by AMD Fusion custom-designed system-on-chip with eight x86 low-power/low-cost Jaguar cores, AMD Radeon HD graphics with GCN architecture as well as 8GB of DDR3 system memory. The console is projected to feature hard disk drive, Blu-ray disc drive as well as robust Xbox Live online service. It is believed that Microsoft Xbox ?Durango? has lower-performance graphics sub-system as well as slower memory sub-system when compared to Sony PS4.

?

An analysis of what is known about the Xbox Next clearly points to the fact that Microsoft had put a great deal of attention to make the Durango a high-quality general-purpose device for the living room, while compromising some of the gaming-related aspects (e.g., graphics performance). The video games for the Microsoft Xbox Next will clearly look better and feel better than titles developed for the Xbox 360 simply because of the eight-year gap in technologies under the hoods of the systems. However, only time will show how future-proof will be Microsoft?s Durango console for the core gamers who demand improvements of titles throughout the active lifetime of the console that could span for eight years, as in the case of the Xbox 360.

Microsoft did not comment on the news-story.

Tags: Microsoft, Xbox, Durango, Xbox Next, Stingray, Loop, AMD, ATI, Radeon, Fusion, Jaguar, GCN

Comments currently: 4
Discussion started: 04/10/13 01:47:15 AM
Latest comment: 04/10/13 10:49:52 AM
Expand all threads | Collapse all threads

[1-2]

1.?

always on = DRM. Thanks, but no thanks M$.
I can wait for 2 min for console to boot up, no problem.

+ expand thread (2 answers) - collapse thread

That is not what they mean. 'Always on' means when the console is on you need to be connected to the internet for it to function correctly.

You can turn the power off when ever you want.

But you are right that it means DRM, but I really don't have any issues with DRM as long as it doesn't massively impede on my system performance. I am more than happy to wait for a game to come down to a price I feel it is worth. The game makers have put a lot of time and money into their games and if we want good, high quality games we have to accept to part with our money. I also think second hand games should be banned too. If there was no piracy and no second hand games then possibly the game price would come down but mainly the games companies would make more money which on the whole will lead to more and better games.

The bigger problem is that Durango will be tightly integrated into Microsoft' ecosystem and will not use any exclusive technologies. Therefore, "always on" requirement and constant DRM will likely be a part of all Microsoft's products going forward.

---

2.?

I can't help but laugh everytime I see the word Durango because ir is very close to the word Drongo which means in Australisn English someone who is an idiot.

[1-2]

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Source: http://www.xbitlabs.com/news/multimedia/display/20130408233854_Microsoft_Xbox_Next_Durango_May_Cost_500_Tech_Analyst.html

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How To Succeed With Home Remodeling Assignments Nowadays ...

Many people attempt to tackle home improvement careers every day. Some be successful, whilst other both crash or find it too difficult to complete and only stop trying. Redesigning will not be tough, presented you will have the appropriate details. The details on this page can assist you when you find yourself undertaking redesigning.

Having a modest cooking area doesn?t must be all poor. As you have constrained areas and room to do business with, make sure to buy a kitchen sink using a serious pan. Then include some elegant higher- end taps to fit all of your kitchen. It is possible to generate feeling of place while not having to affect the rest of your house.

Use high-priced ceramic tiles as an edge or accent inside your flooring undertaking to save money. Pick common ceramic tile for the majority of your neighborhood, and then take advantage of the designer tiles to brighten up the style. This may make your budget low while so you have a stylish bathroom to be pleased with.

When you are not able to choose a color coloration as you will not be confident exactly how the shades can look with your desired area, obtain a tiny bit of painting in several shades to test out in the wall structure. Using a greater shade swatch to look at and analyze inside your room?s lighting effects can help you to make up your mind.

To further improve your property, consider re-framing your entrance. Consider replacing things such as door knobs and fastens in your main entrance. Attempt to pinpoint a substantial take care of-and-locking mechanism set which can be effortlessly set up. Nice tough components of equipment around the door can help communicate that this is a sound home.

An excellent redecorating venture that can be done yourself is to replace your Formica counter tops with tile. Just strip away from the outdated Formica and you should have a strong basic for first time tile. You can choose from thousands of distinct designs and materials to your new counter top.

Instead of purchasing plastic material boxes for under mattress storage space, buy some square baskets. Baskets are a fantastic way to hold items you will need through the day, while keeping any room uncluttered and neat. Plastic-type material doesn?t seem good, but using baskets can be a touch of professionalism and trust in almost any surroundings.

Don?t hire a licensed contractor until finally you discover if they?re covered with insurance! This really is a sure symbol of a reliable professional who is able to full the property improvements you necessary, and therefore they?re not much of a rip-off artist who can consider your hard earned money and operate.

By redoing your driveway with a new method of surfacing or perhaps redoing the existing surfacing is a great home remodeling work that will make your home seem better. You will not only have the capacity to appreciate your home, but everybody in the community will too.

As mentioned well before, people try out home improvement daily. Although some become successful, other surrender or fall short. The right details can make any home improvement task possible. In the event you recall the info through the article previously mentioned, you will certainly be more lucrative at home advancement efforts and much less more likely to crash or surrender.

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nanking adventist: The Age Of Indie Publishing A Book ? Writing and ...

There was a time when getting your book released implied you had to contact one large publishing home after an additional, while being declined by a lot of, if not every one of them, prior to the long for your book became a reality.

Of course you constantly needed to have skill to be a popular author. Nevertheless, in days not so long ago you likewise needed a good supply of cash to support yourself while you were writing, not to point out to get your book pushed through the long procedure of publishing. Connections in the industry, in addition to culture, likewise helped out alot when you wished to get the book, that you worked so tough on and which meant a lot to you, into the hands of the general public.

Even though, as they say, ?The more things alter, the even more they stay the exact same? some things have changed a lot worldwide of publishing. A significant modification was the intro of the computer and the internet.

Now it is simpler than ever before to get your content published

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Tags: self book publishing, Self published book, self publishing

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Was Chilean poet Neruda murdered?

By Rodrigo Garrido

ISLA NEGRA, Chile (Reuters) - The body of Chilean Nobel laureate Pablo Neruda, dead nearly four decades, was exhumed on Monday after his former driver said the poet was poisoned under Augusto Pinochet's dictatorship.

Neruda, famed for his passionate love poems and staunch communist views, is presumed to have died from prostate cancer on September 23, 1973.

But Manuel Araya, who was Neruda's chauffer during the ailing writer's last few months, says agents of the dictatorship took advantage of his illness to inject poison into his stomach while he was bedridden at the Santa Maria clinic in Santiago.

"We're hoping for a positive result because Neruda was assassinated. Pinochet made an error when he ordered Neruda be killed," said Araya. Results are expected in coming months.

Neruda was a supporter of socialist President Salvador Allende, who was toppled in a military coup on September 11, 1973, nearly two weeks before the poet's death at age 69. Around 3,000 people are thought to have been killed by the brutal 17-year-long dictatorship that ensued.

Neruda was buried in his coastal home of Isla Negra beside his third wife, Matilde Urrutia.

His remains will be brought to Santiago for analysis. Some samples could be sent to laboratories abroad.

Ricardo Eliecer Neftali Reyes Basoalto, better known by his pen name Pablo Neruda, was a larger-than-life fixture in Chile's literary and political scene.

While best known for his collection "Twenty Love Poems and a Song of Despair," published in 1924, Neruda was also an important political activist during a turbulent time in Chile.

He organized a ship to bring about 2,000 Spanish refugees fleeing the civil war there to Chile in 1939, campaigned for Allende and was ambassador to France during the socialist's presidency.

The Andean country's intelligentsia frequently congregated in Isla Negra, as well as in his Santiago home "La Chascona" - so named for his then-mistress Urrutia's messy red hair - and La Sebastiana, his ship-themed home in the port town of Valparaiso.

Democratically elected Allende committed suicide in the presidential palace as it was under attack by the military, experts confirmed last year, amid accusations he had been murdered during the coup.

Chilean courts are also investigating the death of ex-President Eduardo Frei Montalva, who is presumed to have died in 1982 of an infection after a hernia operation. Some say he was poisoned by Pinochet's agents.

(Reporting By Rodrigo Garrido; Writing by Alexandra Ulmer; Editing by Eric Beech)

Source: http://news.yahoo.com/chilean-poet-nerudas-body-exhumed-murder-probe-141159039.html

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Engineered T cells kill tumors but spare normal tissue in an animal model

Monday, April 8, 2013

The need to distinguish between normal cells and tumor cells is a feature that has been long sought for most types of cancer drugs. Tumor antigens, unique proteins on the surface of a tumor, are potential targets for a normal immune response against cancer. Identifying which antigens a patient's tumor cells express is the cornerstone of designing cancer therapy for that individual. But some of these tumor antigens are also expressed on normal cells, inching personalized therapy back to the original problem.

T cells made to express a protein called CAR, for chimeric antigen receptor, are engineered by grafting a portion of a tumor-specific antibody onto an immune cell, allowing them to recognize antigens on the cell surface. Early first-generation CARs had one signaling domain for T-cell activation. Second-generation CARs are more commonly used and have two signaling domains within the immune cell, one for T-cell activation and another for T- cell costimulation to boost the T cell's function.

Importantly, CARs allow patients' T cells to recognize tumor antigens and kill certain tumor cells. A large number of tumor-specific, cancer-fighting CAR T cells can be generated in a specialized lab using patients' own T cells, which are then infused back into them for therapy. Despite promising clinical results, it is now recognized that some CAR-based therapies may involve toxicity against normal tissues that express low amounts of the targeted tumor-associated antigen.

To address this issue, Daniel J. Powell Jr., PhD, research assistant professor of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, and director of the Cellular Therapy Tissue Facility, developed an innovative dual CAR approach in which the activation signal for T cells is physically dissociated from a second costimulatory signal for immune cells. The two CARs carry different antigen specificity -- mesothelin and a-folate receptor. Mesothelin is primarily associated with mesothelioma and ovarian cancer, and a-folate receptor with ovarian cancer.

Powell likens this dual CAR approach to having two different gas pedals, one for starting the immune system and a second for revving it up. Dual CAR T cells are more selective for tumor cells since their full activity requires interaction with both antigens, which are only co-expressed on tumor cells, not normal tissue.

Dual CAR T cells showed weak cytokine production against target cells expressing only one tumor-associated antigen in lab assays, similar to first-generation CAR T cells bearing the CD3 activation domain only, but demonstrated enhanced cytokine production upon encountering natural or engineered tumor cells expressing both antigens, equivalent to second-generation CAR T cells with dual, but unseparated signaling.

In a mouse model of human ovarian cancer, T cells with the dual-signaling CARs persisted at high numbers in the blood, accumulated in tumors, and showed potent anti-cancer activity against human tumors. Dual CAR T cells were equivalent to second-generation CAR T cells in activity against tumors bearing two antigens. However, the dual-signaling CAR T cells did not react vigorously with normal tissue expressing one antigen while second- generation CAR T cells did.

"This new dual-specificity CAR approach can enhance the therapeutic efficacy of CAR T cells against cancer while minimizing reactivity against normal tissues," says Powell.

Their findings have been published in the inaugural issue of Cancer Immunology Research, the newest journal from the American Association for Cancer Research.

###

University of Pennsylvania School of Medicine: http://www.uphs.upenn.edu/news/

Thanks to University of Pennsylvania School of Medicine for this article.

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PSA: HTC One pre-orders start at AT&amp;T today, Sprint tomorrow

You've been eying the HTC One's zero-gap body for well over a month, and now it's your chance to do something about it. AT&T is launching its promised pre-order campaign for the One today: soon, if not as you read this, upgraders and new subscribers can plunk down as little as $200 for a 32GB model or $300 for the network-exclusive 64GB edition. While these buyers likely won't get their phones until closer to the April 19th store date, that free Media Link HD offer remains on the table to encourage an early commitment. And those who prefer service from the House of Hesse don't have long to wait, either -- Sprint's pre-orders for the One begin tomorrow, with a similar $200 outlay involved for the 32GB variant. All that's left is for T-Mobile's edition to follow suit.

Filed under: Cellphones, Mobile, HTC, Sprint, AT&T

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Scientists find possible hint of dark matter

This undated file image provided by the European Space Agency ESA on Wednesday April 3, 2013 shows the International Space Station in the sunlight. A $2 billion cosmic ray detector on the International Space Station has found the footprint of something that could be dark matter, the mysterious substance that is believed to hold the cosmos together but has never been directly observed, scientists say. But the first results from the Alpha Magnetic Spectrometer, known by its acronym AMS, are almost as enigmatic as dark matter itself. They show evidence of new physics phenomena that could be the strange and unknown dark matter or could be energy that originates from pulsars, scientists at the European particle physics laboratory near Geneva announced Wednesday April 3, 2013. (AP Photo/NASA/European Space Agency ESA. Keystone)

This undated file image provided by the European Space Agency ESA on Wednesday April 3, 2013 shows the International Space Station in the sunlight. A $2 billion cosmic ray detector on the International Space Station has found the footprint of something that could be dark matter, the mysterious substance that is believed to hold the cosmos together but has never been directly observed, scientists say. But the first results from the Alpha Magnetic Spectrometer, known by its acronym AMS, are almost as enigmatic as dark matter itself. They show evidence of new physics phenomena that could be the strange and unknown dark matter or could be energy that originates from pulsars, scientists at the European particle physics laboratory near Geneva announced Wednesday April 3, 2013. (AP Photo/NASA/European Space Agency ESA. Keystone)

FILE - In this July 25, 2012 file picture Director general of CERN Rolf-Dieter Heuer, left, Nobel laureate and AMS spokesperson Samuel C.C. Ting, right, and Mark Kelly, NASA astronaut and commander of mission STS-134, center, brief the media at the Alpha Magnetic Spectrometer (AMS) Payload Operations and Command Center (POCC) at the European Organization for Nuclear Research (CERN) in Meyrin near Geneva, Switzerland. A US $2 billion experiment on the International Space Station is on the verge of explaining one of the more mysterious building blocks of the universe: The dark matter that helps hold the cosmos together. An international team of scientists says the cosmic ray detector has found the first hint of dark matter, which has never yet been directly observed. The team said Wednesday its first results from the Alpha Magnetic Spectrometer, flown into space two years ago, show evidence of a new physics phenomena that could be the strange and unknown matter. Nobel-winning physicist Samuel Ting, who leads the team at the European particle physics laboratory near Geneva, says he expects a more conclusive answer within months. The findings are based on an excess of positrons positively charged subatomic particles. (AP Photo/Keystone/Martial Trezzini,File)

FILE -In this undated picture made available by NASA, a technician examines the Alpha Magnetic Spectrometer at Kennedy Space Center in Cape Canaveral, Fla.. The cosmic ray detector was mounted on the International Space Station, searched the universe and shall help to explain how everything came to be. CERN , the European Organization for Nuclear Research, released first results of the experiment Wednesday April 3, 2013. (AP Photo/NASA, Glenn Benson)

FILE - This undated image shows an artist's concept of the Alpha Magnetic Spectrometer, rounded module at left, installed on the International Space Station provided by NASA. The cosmic ray detector searched the universe and shall help to explain how everything came to be. CERN , the European Organization for Nuclear Research, released first results of the experiment Wednesday April 3, 2013. (AP Photo/NASA)

GENEVA (AP) ? It is one of the cosmos' most mysterious unsolved cases: dark matter. It is supposedly what holds the universe together. We can't see it, but scientists are pretty sure it's out there.

Led by a dogged, Nobel Prize-winning gumshoe who has spent 18 years on the case, scientists put a $2 billion detector aboard the International Space Station to try to track down the stuff. And after two years, the first evidence came in Wednesday: tantalizing cosmic footprints that seem to have been left by dark matter.

But the evidence isn't enough to declare the case closed. The footprints could have come from another, more conventional suspect: a pulsar, or a rotating, radiation-emitting star.

The Sam Spade in the investigation, physicist and Nobel laureate Sam Ting of the Massachusetts Institute of Technology, said he expects a more definitive answer in a matter of months. He confidently promised: "There is no question we're going to solve this problem."

"It's a tantalizing hint," said California Institute of Technology physicist Sean Carroll, who was not part of the team. "It's a sign of something." But he can't quite say what that something is. It doesn't eliminate the other suspect, pulsars, he added.

The results from the Alpha Magnetic Spectrometer, or AMS, are significant because dark matter is thought to make up about a quarter of all the matter in the universe.

"We live in a sea of dark matter," said Michael Salamon, who runs the AMS program for the U.S. Energy Department. Unraveling the mystery of dark matter could help scientists better understand the composition of our universe and, more particularly, what holds galaxies together.

Ting announced the findings in Geneva at the European Organization for Nuclear Research, the particle physics laboratory known as CERN.

The 7-ton detector with a 3-foot magnet ring at its core was sent into space in 2011 in a shuttle mission commanded by astronaut Mark Kelly while his wife, then-Rep. Gabrielle Giffords, was recovering from a gunshot wound to the head. The device is transmitting its data to CERN, where it is being analyzed.

For 80 years scientists have theorized the existence of dark matter but have never actually observed it directly. They have looked for it in accelerators that smash particles together at high speed. No luck. They've looked deep underground with special detectors. Again no luck.

Then there's a third way: looking in space for the results of rare dark matter collisions. If particles of dark matter crash and annihilate each other, they should leave a footprint of positrons ? the anti-matter version of electrons ? at high energy levels. That's what Ting and AMS are looking for.

They found some. But they could also be signs of pulsars, Ting and others concede. What's key is the curve of the plot of those positrons. If the curve is one shape, it points to dark matter. If it's another, it points to pulsars. Ting said they should know the curve ? and the suspect ? soon.

The instrument will be measuring cosmic rays, where the footprints are found, until 2020 or so.

Other scientists praised the results and looked forward to more.

"This is an 80-year-old detective story and we are getting close to the end," said University of Chicago physicist Michael Turner, one of the giants in the field of dark matter. "This is a tantalizing clue and further results from AMS could finish the story."

___

Borenstein reported from Washington.

___

Online:

NASA: http://www.nasa.gov/shuttle

Alpha Magnetic Spectrometer: http://www.ams02.org

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-03-Switzerland-Cosmic%20Rays/id-e003bd4281dd4ec4bf59de404a5cddbb

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Leno to leave NBC's 'Tonight Show' next spring

This undated promotional image released by NBC shows Jay Leno, host of "The Tonight Show with Jay Leno," left, and Jimmy Fallon, host of "Late Night with Jimmy Fallon," in Los Angeles. NBC on Wednesday, April 3, 2013 announced its long-rumored switch in late night, replacing incumbent Jay Leno at "The Tonight Show" with Jimmy Fallon and moving the iconic franchise back to New York. Leno will wrap up what will be 22 years of headlining the iconic late-night show in Spring 2014. "Saturday Night Live" producer Lorne Michaels will take over as producer of the new "Tonight Show." (AP Photo/NBC, Andrew Eccles)

This undated promotional image released by NBC shows Jay Leno, host of "The Tonight Show with Jay Leno," left, and Jimmy Fallon, host of "Late Night with Jimmy Fallon," in Los Angeles. NBC on Wednesday, April 3, 2013 announced its long-rumored switch in late night, replacing incumbent Jay Leno at "The Tonight Show" with Jimmy Fallon and moving the iconic franchise back to New York. Leno will wrap up what will be 22 years of headlining the iconic late-night show in Spring 2014. "Saturday Night Live" producer Lorne Michaels will take over as producer of the new "Tonight Show." (AP Photo/NBC, Andrew Eccles)

FILE - This Jan. 13, 2013 file photo shows Jay Leno, host of "The Tonight Show with Jay Leno," left, and Jimmy Fallon, host of "Late Night with Jimmy Fallon" backstage at the 70th Annual Golden Globe Awards in Beverly Hills, Calif. As Jay Leno lobs potshots at ratings-challenged NBC in his "Tonight Show" monologues, speculation is swirling the network is taking steps to replace the host with Jimmy Fallon next year and move the show from Burbank to New York. NBC confirmed Wednesday, March 20, it's creating a new studio for Fallon in New York, where he hosts "Late Night." But the network did not comment on a report that the digs at its Rockefeller Plaza headquarters may become home to a transplanted, Fallon-hosted "Tonight Show." (Photo by Jordan Strauss/Invision/AP, file)

This Nov. 5, 2012 photo released by NBC shows Jay Leno, host of "The Tonight Show with Jay Leno," on the set in Burbank, Calif. As Jay Leno lobs potshots at ratings-challenged NBC in his "Tonight Show" monologues, speculation is swirling the network is taking steps to replace the host with Jimmy Fallon next year and move the show from Burbank to New York. NBC confirmed Wednesday, March 20, it's creating a new studio for Fallon in New York, where he hosts "Late Night." But the network did not comment on a report that the digs at its Rockefeller Plaza headquarters may become home to a transplanted, Fallon-hosted "Tonight Show." (AP Photo/NBC, Paul Drinkwater)

This Oct. 24, 2012 photo released by NBC shows Jay Leno, host of "The Tonight Show with Jay Leno," on the set in Burbank, Calif. NBC announced Wednesday, April 3, 2013 that Jimmy Fallon is replacing Jay Leno as the host of "The Tonight Show" in spring 2014. (AP Photo/NBC, Paul Drinkwater)

This Feb. 18, 2013 photo released by NBC shows Jimmy Fallon, host of "Late Night with Jimmy Fallon," on the set in New York. As Jay Leno lobs potshots at ratings-challenged NBC in his "Tonight Show" monologues, speculation is swirling the network is taking steps to replace the host with Jimmy Fallon next year and move the show from Burbank to New York. NBC confirmed Wednesday, March 20, it's creating a new studio for Fallon in New York, where he hosts "Late Night." But the network did not comment on a report that the digs at its Rockefeller Plaza headquarters may become home to a transplanted, Fallon-hosted "Tonight Show." (AP Photo/NBC, Lloyd Bishop)

NEW YORK (AP) ? NBC on Wednesday announced its long-rumored switch in late night, replacing Jay Leno at the "Tonight" show with Jimmy Fallon and moving the iconic franchise back to New York.

Fallon will take over in about a year, the switch coinciding with NBC's coverage of the 2014 Winter Olympics. Veteran "Saturday Night Live" producer Lorne Michaels also will take over as executive producer of "Tonight."

NBC made no announcement on who would replace Fallon at the 12:35 a.m. "Late Night" slot, although Seth Meyers of "Saturday Night Live" is considered a strong candidate.

The change at "Tonight," the longest-running and most popular late-night talk show, had been widely reported but not confirmed by the network until Wednesday. NBC reportedly just wrapped up negotiations with Fallon on a contract extension.

Steve Burke, chief executive officer of NBC Universal, said the network is purposefully making the move when Leno is still at the top of the ratings, just as when Leno replaced Johnny Carson at "Tonight" in 1992.

"Jimmy Fallon is a unique talent, and this is his time," Burke said.

Leno, in a statement, offered his congratulations to Fallon.

"I hope you're as lucky as me and hold on to the job until you're the old guy," he said. "If you need me, I'll be at the garage."

Fallon said, "I'm really excited to host a show that starts today instead of tomorrow."

Emotions were mixed among people waiting outside Leno's Burbank, Calif., studio to attend the taping of Wednesday's "Tonight" show.

"We love you, Jimmy!" said Natalie Renfro, 45, of Salt Lake City. But she gave a shout out to Leno, too: "I'll miss that big chin!"

Ryan Kelly, 39, of Los Angeles, said he's a Leno fan but added that the comedian has "had a good run. ... It's probably time for a fresh face. He's done a good job and I'm sure he'll pop up on TV somewhere else."

As for switching to Fallon, "I'll give it a shot," Kelly said.

Leno couldn't resist a jab at NBC in his monologue Wednesday, even as he as he lauded Fallon as "a hell of a guy" who is going to do a "great job."

"I just have one request for Jimmy: We've all fought, kicked and scratched to get this network up to fifth place. Now we have to keep it there. Jimmy, don't let it slip into sixth!" Leno joked, according to an NBC transcript.

Fallon took a puckish approach in his monologue.

"Welcome! This is 'Late Night with Jimmy Fallon ... for now," he said. "You guys probably heard the news: I'm going to be taking over the 'Tonight Show' next February! But don't worry. Until February, our focus is right here on whatever this show is called."

On his "Late Show" Wednesday on CBS, David Letterman feasted on NBC's announcement.

"Jay Leno now is being replaced, and this is the second time this has happened," he said in his monologue. "I mean, it's crazy. He's being replaced by a younger late night talk show host ? what could possibly go wrong? Honestly. They had pretty good luck with this in the past."

Later, Letterman offered a backhanded salute to Leno that wished him well with his stand-up appearances.

"But good luck to Jay. I know he'll be out on the road, getting it done and taking care of business. And congratulations on a nice long run there at the 'Tonight Show,' if, in fact, you're not coming back," Letterman said, according to a CBS transcript.

He devoted his Top 10 list to "things we'll miss about Jay Leno," including this at No. 4: "Can't remember the name of the bit, but it's the one where Jay is walking."

NBC has been quietly building a new studio for Fallon at its Rockefeller Center headquarters. "Tonight" began in New York in the 1950s, but Carson moved it to California in 1972. Starting next year, Fallon, Letterman, Jon Stewart and Stephen Colbert will tape late-night shows in New York. ABC's Jimmy Kimmel and TBS's Conan O'Brien will be the top California-based shows.

"The 'Tonight' show will bring even more jobs and economic activity to our city, and we couldn't be happier that one of New York's own is bringing the show back to where it started, and where it belongs," said New York Mayor Michael Bloomberg.

New York state recently added a tax credit in its budget that seemed designed specifically to benefit NBC's move east with "Tonight."

While a storied part of television tradition, the network late-night shows find themselves with much more competition now with cable programs like "Adult Swim," smaller talk shows hosted by Chelsea Handler and the Comedy Central duo of Stewart and Colbert, and a device ? a large number of people take that time to watch programs they had taped earlier on their DVRs.

NBC is worried that Kimmel will establish himself as a go-to late night performer for a younger generation if the network doesn't move swiftly to install Fallon. ABC moved Kimmel's time slot to directly compete with Leno earlier this year.

But the move also has the potential to backfire with Leno's fans, who did not embrace O'Brien when Leno was temporarily moved to prime time a few years ago.

"The guys at NBC are not totally stupid and are not going to shoot themselves in the foot," said Gary Carr, senior vice president and executive director of national broadcast for the ad buying firm TargetCast. "I think it's a good move for them long-term. But it may have short-term ramifications."

NBC has long prided itself on smooth transitions, but that reputation took a hit with the short-lived and ill-fated move of O'Brien to "Tonight" and Leno to prime time. In morning television, the "Today" show has taken a ratings nose dive in large measure because of anger at how Ann Curry was treated when she was ousted last year as Matt Lauer's co-host.

The Leno-Fallon changeover didn't begin smoothly. Leno had been cracking jokes about NBC's prime-time futility, angering NBC entertainment chief Robert Greenblatt, who sent a note to Leno telling him to cool it. That only made Leno go after NBC management much harder.

The first public effort toward making the transition smooth came Monday night, when Leno and Fallon appeared in a comic video making fun of the late-night rumors. It aired in between each man's show.

John Dawson, general manager for five NBC affiliates that have extensive reach throughout Kansas, said it will be difficult to give up a program that wins its time period by 33 percent.

"Jay has always been a great friend to the affiliates," he said. "For that alone it will be hard to give up."

But he said he believes in Fallon and in NBC's corporate owner, Comcast Corp., the nation's largest cable company.

"Comcast certainly knows how to launch entertainment programming," Dawson said.

___

Associated Press television writers Lynn Elber in Los Angeles and Frazier Moore in New York, and AP writer Nicole Evatt in Los Angeles contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-04-03-NBC-Leno/id-d43b602048044d4281d4b51e3ac026da

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